a Record control number 000321475000008

a ISSN 0378-8741

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QU145

b Item number .C66 2013

a Personal name Renda, Gulin.

h Medium Electronic Document

a Title Comparative assessment of dermal wound healing potentials of various Trifolium L. extracts and determination of their isoflavone contents as potential active ingredients

c Statement of responsibility, etc Gülin Renda, Funda N. Yalçın, Emirhan Nemutlu, Ersa Küpeli Akkol, İpek Suntar, Hikmet Keles, Hiroji İna, İhsan Çalış, Tayfun Ersöz.

b Name of publisher, distributor, etc Elsevıer Ireland Ltd

c Date of publication, distribution, etc 2013.

a Summary, etc Ethnopharmacological relevance: Tnfolium species are used in Turkish folk medicine as a wound healing agent, expectorant, antiseptic, sedative and to alleviate pain in rheumatism. In the present study, the aqueous methanolic extracts (80%) of 13 Trifolium species (Trifolium ambigum, Trifolium arvense var. arvense, Trifolium campestre, Trifolium canescens, Trifolium hybridum var. anatolicum, Trifolium hybridum var. hybridum, Tnfolium pannonicum, Tnfolium pratense var. pratense, Trifolium purpureum var. puipureum, Tnfolium repens var. repens, Tnfolium resupinatum var. microcephalum, Tnfolium spadiceum and Trifolium trichocephalum) collected from different regions of Anatolia were evaluated for their in vivo wound healing effects. Materials and methods: In vivo wound healing activities of the plant aqueous methanolic extracts were evaluated by linear incision and circular excision wound models subsequent to histopathological analysis. Active constituents were determined by a validated high performance liquid chromatographic method. Precision of the method was performed by the evaluation of intra-day and inter-day variations of the each standard at limits of quantification (LOQ) levels. Results: The aqueous methanolic extracts of Tnfolium canescens and Trifolium pretense var. pratense possessed better wound healing activity compared to the other extracts and control groups. The animal groups treated with the Trifolium canescens extract demonstrated increased contraction (48.96%) on excision and a significant increase in wound tensile strength (35.6%) on incision models. The main compounds were detected as genistein and biochanin A for Trifolium canescens. Conclusion: The results of the present study revealed the wound healing potential of Tnfolium canescens. This might be due to the combined effect of the isoflavones genistein, formononetin, daidzein, and biochanin A present in the extract. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Wound Healing

a Topical term or geographic name as entry element Isoflavones

a Topical term or geographic name as entry element Incision

a Topical term or geographic name as entry element Performance Lıquıd-Chromatography

a Topical term or geographic name as entry element Protects Dopamınergıc-Neurons

a Topical term or geographic name as entry element Spectrometrıc detectıon;

a Topical term or geographic name as entry element Genısteın

a Topical term or geographic name as entry element Antıoxıdant

g Relationship information Jul 9 2013, Vol.148, Issue:2, p. 423-432

t Title Journal Of Ethnopharmacology

x International Standard Serial Number 03788741

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.jep.2013.04.031